James Khan
MSc, MD, FRCPC
Dr. James Khan is an Assistant Professor and Clinician-Scientist in the Department of Anesthesia and Pain Medicine at the University of Toronto. He completed his medical school training at McMaster Medical School where he graduated as his class Valedictorian. He completed residency training in Anesthesiology at the University of Toronto and fellowship training in Pain Medicine at Stanford University. Dr. Khan also obtained a Master of Science in Clinical Epidemiology from McMaster University. He was selected as the 2020 United States Association for the Study of Pain Young Investigator of the Year. He has published over 70 peer-reviewed scientific papers with many papers focused on understanding the transition from acute to chronic pain. He currently practices at Mount Sinai Hospital in Toronto. Dr. Khan serves as the Director of the Persistent Breast Cancer Pain Clinic at Mount Sinai Hospital and is a national expert in the implantation of Peripheral Nerve Stimulators. He also serves as the Research Lead for the Division of Pain Medicine at UofT and the Co-Director of Research for the Toronto Academic Pain Medicine Institute. His current clinical research program that focuses on identifying novel interventions to prevent and treat chronic pain disorders, specifically he leads the PLAN Trial which is an international multicentre randomized controlled trial in 1,602 patients which aims to evaluate whether an intraoperative intravenous lidocaine infusion can prevent persistent pain after breast cancer surgery.
Publications
Pepper CG, Mikhaeil JS, Khan JS. Perioperative Regional Anesthesia on Persistent Opioid Use and Chronic Pain After Noncardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Anesthesia & Analgesia 2024; 139(4):711-722. doi: 10.1213/ANE.0000000000006947.
Khan JS, Gilron I, Devereaux PJ, Clarke H, Ayach N, Tomlinson G, Quan ML, Ladha KS, Choi S, Munro A, Brull R, Lim DW, Avramescu S, Richebé P, Hodgson N, Paul J, McIssac DI, Derzi S, Zbitnew GL, Easson AM, Siddiqui NT, Miles SJ, Karkouti K, and PLAN Trial Investigators. Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial. Trials 2024; 25(337): 1-13.
Mazzolenis MV, Mourra GN, Moreau S, Mazzolenis ME, Cerda IH, Vega J, Khan JS, Thérond A.
The Role of Virtual Reality and Artificial Intelligence in Cognitive Pain Therapy: A Narrative Review. Current Pain and Headache Reports 2024: 1-2. https://doi.org/10.1007/s11916-024-01270-2.
Gilron I, DeBow C, Elkerdawy H, Khan JS, Salomons TV, Duggan S, Tu D, Holden RR, Milev R, Buckley DN, Moulin DE. PRECISE trial (Pain Relief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin-melatonin combination for fibromyalgia. BMJ Open 2024 Jun 1;14 (6): 1-8. (Open access)
Al-Asadi M, Torabiardakani K, Darzi AJ, Gilron I, Marcucci M, Khan JS, Chaparro LE, Rosenbloom B, Couban RJ, Thomas A, Busse JW, Sadeghirad B. Comparative benefits and harms of perioperative interventions to prevent chronic pain after orthopedic surgery: A systematic review and network meta-analysis of randomised trials. Systematic Reviews 2024; 13(114): 1-7. (Open access)
Dana E, Arzola C, Khan JS. Prevention of hypotension after induction of general anesthesia using point-of-care ultrasound to guide fluid management: a randomized controlled trial. Canadian Journal of Anesthesia 2024; 13: 1-10. https://doi.org/10.1007/s12630-024-02748-8.
Dana E, Dana HK, De Castro C, Bueno Rey L, Li Q, Tomlinson G, Khan JS. Inferior Vena Cava Ultrasound to Predict Hypotension after General Anesthesia Induction: A Systematic Review and Meta-Analysis. Canadian Journal of Anesthesia 2024; 71: 1078–1091.
Di Renna T, Burke E, Bhatia A, Clarke H, Flamer D, Flannery J, Furlan A, Khan J, Ladha K, Smith A, Sussman D, Bosma R. Improving access to chronic pain care with central referral and triage: The 5-year findings from a single-entry model. Canadian Journal of Pain 2024; 8(1): 1-9. DOI: 10.1080/24740527.2023.2297561.
Gouveia K, Sprague S, Gallant J, Del Fabbro G, Leonard J, Bzovsky S, McKay P, Busse JW, and COPE Investigators (J Khan). In-person cognitive behavioural therapy vs. usual care after surgical management of extremity fractures: an unsuccessful feasibility trial. Pilot and Feasibility Studies. 2024 Jan;10(1):1-7.
Dana E, Tran C, Osokin E, Westwood D, Moayedi M, Sabhaya P, Khan JS. Peripheral magnetic stimulation for chronic peripheral neuropathic pain: A systematic review and meta-analysis. Pain Practice 2023 Dec 16. Doi: 10.1111/papr.13332.
Khan JS, D’hondt N, Hoydonckx Y, Poddar M, Carroll I. Glucagon-like peptide-1 analogue in the management of rebound intracranial hypertension: a case report. Annals of Headache Medicine 2023; 11:02. DOI: 10.30756/ahmj.2023.11.02.
Alomari A, Ferreira-Dos-Santos G, Singh M, Burnham T, Cao X, McCormick Z, Flamer D, Kumar P, Hoydonckx Y, Khan JS, Tumber PS, Alvares D, Bhatia A. End‑on versus parallel radiofrequency lesioning for neurotomy of the cervical medial branch nerves: a study protocol of a prospective, randomized, double‑blind clinical trial: the “EndPaRL” study. Trials 2023; 24:721.
Khan JS, Dana E, Xiao MZ, Rao V, Djaiani G, Seltzer Z, Ladha K, Huang A, McRae K, Cypel M, Katz J, Wong D, Clarke H. Prevalence and risk factors for chronic post-surgical pain following thoracic surgery: a prospective cohort study. Journal of Cardiothoracic and Vascular Anesthesia 2023. https://doi.org/10.1053/j.jvca.2023.09.042.
Xiao MZ, Khan JS, Dana E, Rao V, Djaiani G, Richebé P, Katz J, Wong D, Clarke H. Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Cardiac Surgery: A Single-center Prospective Cohort Study. Anesthesiology 2023; 139: 309-320.
Pagé MG, Ganty P, Wong D, Rao V, Khan JS, Ladha K, Hanlon J, Miles S, Katznelson R, Wijeysundera D, Katz J, Clarke H. A prospective cohort study of acute pain and in-hospital opioid consumption after cardiac surgery: Associations with psychological and medical factors and chronic postsurgical pain. Anesthesia & Analgesia 2023. In Press.
Sahni S, Patel R, Wang L, Miles S, Dana E, Khan JS. Characteristics and perioperative risk factors for persistent pain after breast cancer surgery: a prospective cohort study. Surgeries 2023; 4(3): 301-316
Nguyen LH, Dawson JE, Brooks M, Khan JS, Telusca N. Disparities in Pain Management. Anesthesiology Clinics. 2023;41(2):471-88.
Dana E, Nour M, Kpa H, Khan JS. Point-of-Care Ultrasound (PoCUS) and its potential to advance patient care in low-resource settings and conflict zones. Disaster Medicine and Public Health Preparedness 2023; 17: p.e417.
Hoydonckx Y, Singh M, Gilron I, Khan J, Narouze S, Dahan A, Curtis K, Cao X, Kara J, Bhatia A. Trial protocol for a multicenter randomized controlled trial to assess the efficacy and safety of intravenous ketamine for chronic daily headaches: the "KetHead" trial. Trials. 2023 Mar 1;24(1):155. doi: 10.1186/s13063-023-07186-3. PMID: 36855160.
Busse, J.W. and Sprague, S. on behalf of the COPE Investigators (Khan, J). Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial. Trials 2022; 23(1): p.894.
Khan JS, Westwood D, Moayedi M. Ultrasound-guided repetitive pulsed peripheral magnetic stimulation provides pain relief in refractory glossopharyngeal neuralgia: A case report. Canadian Journal of Pain 2023; 7(1): 1-5.
Dana E, Gupta H, Pathak R, Khan JS. Genitofemoral peripheral nerve stimulator implantation for refractory groin pain: a case report. Canadian Journal of Anesthesia 2022. doi.org/10.1007/s12630-022-02348-4
Devereaux PJ, Lamy A, Chan MT, on behalf of the VISION Cardiac Surgery Investigators (Khan J). High-sensitivity troponin I after cardiac surgery and 30-day mortality. New England Journal of Medicine 2022; 386(9): 827-836.
McGillion MH, Parlow J, Borges FK, on behalf of the PVC-RAM Investigators (Khan J). Post-discharge after surgery Virtual Care with Remote Automated Monitoring-1 (PVC-RAM-1) technology versus standard care: randomised controlled trial. BMJ 2021. 374: 1-11.
Khan JS, Sessler DI, Chan MTV, Wang CY, Garutti I, Szczeklik W, Turan A, Busse J, Buckley DN, Paul J, McGillion M, Fernández-Riveira C, Srinathan SK, Shanthanna H, Gilron I, Jacka M, Jackson P, Hankinson J, Paniagua P, Petit S, Devereaux PJ. Persistent incisional pain after noncardiac surgery: an international prospective cohort study. Anesthesiology 2021; 135(4): 711-723.
Mazda Y, Jadin S, and Khan JS. Postoperative Pain Management. Canadian Journal of General Internal Medicine 2021; 16(SP1): 5-17.
Liu CW, Page MG, Weinrib A, Wong D, Huang A, McRae K, Fiorellino J, Tamir D, Kahn M, Katznelson R, Ladha K, Abdallah F, Cypel M, Yasufuku K, Chan V, Parry M, Khan J, Katz J, Clarke H. Predictors of one-year chronic post-surgical pain trajectories following thoracic surgery. Journal of Anesthesia 2021; 18: 1-10.
Mohiuddin M, Pivetta B, Gilron I, Khan JS. Efficacy and Safety of N-acetylcysteine for the Management of Chronic Pain in Adults: A Systematic Review & Meta-analysis. Pain Medicine 2021; 22(12): 2896-2907.
Liubchenko K, Kordbacheh K, Khajehdehi N, Visnjevac T, Ma F, Khan JS, Storey M, Abd-Elsayed A, Visnjevac O. 2020. Naltrexone’s Impact on Cancer Progression and Mortality: A Systematic Review of Studies in Humans, Animal Models, and Cell Cultures. Advances in Therapy 2021; 38(2): 904-924.
McGillion MH, Parlow J, Borges FK, et al. on behalf of the PVC-RAM Investigators (Khan J). Post Discharge after Surgery Virtual Care with Remote Automated Monitoring Technology (PVC-RAM): protocol for a randomized controlled trial. CMAJ Open. 2021; 9(1): E680-E680
Balki I, Khan JS, Staibano P, Duceppe E, Bessissow A, Sloan EN, Morley EE, Thompson AN, Devereaux B, Rojas C, Rojas C, Siddiqui N, Sessler DI, Devereaux PJ. Effect of perioperative active body surface warming systems on analgesic and clinical outcomes: A systematic review and meta-analysis of randomized controlled trials. Anesthesia & Analgesia 2020: 131(5), pp.1430-1443.
Wang L, Cohen JC, Devasenapathy N, Hong BY, Kheyson S, Lu D, Oparin Y, Kennedy SA, Romerosa B, Arora N, Kown HY, Jackson K, Prasad M, Jayasekera D, Li A, Guarna G, Natalwalla S, Couban RJ, Reid S, Khan JS, McGillion M, Busee JW. Prevalence and intensity of persistent postsurgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies. British Journal of Anaesthesia 2020: 125 (3); 346-357.
Jibb LA, Khan JS, Seth P, Lalloo C, Mulrooney L, Nicholson K, Nowak DA, Kaur H, Chee-A-Tow A, Foster J, Stinson JN. Electronic data capture versus conventional data collection methods in clinical pain studies: a systematic review and meta-analysis. Journal of Medical Internet Research 2020: 22(6); DOI: 10.2196/16480.
Borges FK, Bhandari M, Guerra-Farfan E, et al. on behalf of Hip ATTACK Investigators (Khan JS). Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. The Lancet 2020: 395(10225); 698-708. doi: 10.1016/S0140-6736(20)30058
Khan JS, Ladha KS, Abdallah F, Clarke H. Treating chronic pain post-breast cancer surgery. Drugs 2020: 80(1); 23-31.
Sturgeon JA, Khan JS, Hah JM, Hilmoe H, Hong J, Ware MA, Mackey SC. Clinical profiles of concurrent cannabis use in chronic pain: A CHOIR study. Pain Medicine 2020. doi: 10.1093/pm/pnaa060.
Khan JS, Shah R, Gilron I. Outcomes in Pain Clinical Research: What Really Matters for Patients? Current Anesthesiology Reports 2019: 9(4): 414-421.
Khan JS, Hah JM, Mackey SC. Effects of smoking on patients with chronic pain: a propensity-weighted analysis on the Collaborative Health Outcomes Information Registry. PAIN 2019: 160(10); 2374-2379.
Roshanov PS, Sheth T, Duceppe E, Tandon V, Bessissow A, Chan MTV, Butler C, Chow BJW, Khan JS, Devereaux PJ. Relationship between perioperative hypotension and perioperative cardiovascular events in patients with coronary artery disease undergoing major noncardiac surgery. Anesthesiology 2019: 130(5);756-766.
Khan JS, Jibb LA, Busse JW, Gilron I, Choi S, Paul JE, McGillion M, Mackey S, Buckley DN, Lee SF, Devereaux PJ. Electronic versus traditional data collection: A multicenter randomized controlled perioperative pain trial. Canadian Journal of Pain 2019: 3(2);16-25.
Khan JS, Hodgson N, Choi S, Reid S, Paul JE, Look Hong NJ, Holloway C, Busse JW, Gilron I, Buckley DN, McGillion M, Clarke H, Katz J, Mackey S, Avram R, Pohl K, Rao-Melacini P, Devereaux. Perioperative pregabalin and intraoperative lidocaine infusion to reduce persistent neuropathic pain after breast cancer surgery: a multicenter, factorial, randomized controlled pilot trial. Journal of Pain 2019. S1526-5900(18)30519-4. doi: 10.1016/j.jpain.2019.02.010.
MH McGillion, S Henry, JW Busse, C Ouellette, J Katz, M Choinière, A Lamy, R Whitlock, S Pettit, J Hare, K Gregus, K Brady, N Dvirnik, S Yang, J Parlow, D Dumerton-Shore, I Gilron, DN Buckley, H Shanthanna, SL Carroll, PC Coyte, S Ebrahim, W Isaranuwatchai, DN Guerriere, J Hoch, J Khan, J MacDermid, G Martorella, JC Victor, J Watt-Watson, K Howard-Quijano, A Mahajan, MTV Chan, H Clarke, PJ Devereaux. Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study. BMJ Open 2019;0:e022995. doi:10.1136/bmjopen-2018-022995
Khan JS, Krane EJ, Higgs M, Pritzlaff S, Hoffinger S, Ottestad O. A case report of combined ultrasound and fluoroscopic-guided percutaneous radiofrequency lesioning of the obturator and femoral articular branches in the treatment of persistent hip pain in a pediatric patient. Pain Practice 2018; 19(1): 52-56.
Wang L, Hong BY, Kennedy SA, Chang Y, Hong CJ, Craigie S, Kwon HY, Romerosa B, Couban RJ, Reid S, Khan JS, McGillion M, Blinder V, Busse JW. Predictors of Unemployment After Breast Cancer Surgery: A Systematic Review and Meta-Analysis of Observational Studies. J Clin Oncol 2018; 36(18): 1868-1879. doi: 10.1200/JCO.2017.77.3663.
Oh J, Page MG, Zhong T, McCluskey S, Srinivas C, O’Neill AC, Khan J, Katz J, Hofer SOP, Clarke H. Chronic Postsurgical Pain Outcomes in Breast Reconstruction Patients Receiving Perioperative Transversus Abdominis Plane Catheters at the Donor Site: A Prospective Cohort Follow-up Study. Pain Practice 2017; 17 (8): 999-1007. doi: 10.1111/papr.12550.
Khan JS, Devereaux PJ, LeManach Y, Busse JW. Patient coping and expectations about recovery predict the development of chronic post-surgical pain after traumatic tibial fracture repair. Brit J Anaesth 2016; 117(3): 365-370.
Wang L, Guyatt GH, Kennedy SA, Romerosa B, Kwon HY, Kaushal A, Chang Y, Craigie S, de Almeida CPB, Couban RJ, Parascandalo SR, Izhar Z, Reid S, Khan JS, McGillion M, Busse JW. Predictors of Persistent Pain Following Breast Cancer Surgery: A Systematic Review and Meta-analysis of Observational Studies. CMAJ 2016; 188(14): E352-E361. DOI:10.1503/cmaj.151276.
McGillion M, Devereaux PJ, Turner A, et al. (Khan JS). THE SMArT VIEW, CoVeRed: TecHnology Enabled monitoring and Self-MAnagemenT- VIsion for patient EmpoWerment following Cardiac and VasculaR surgery. JMIR Research Protocols 2016: 5(3).
Sharma A, Khan JS, Stanifer JW, Seth P. The importance of global health experiences during clinical training. J Am Coll Cardiol, May 2016; 67 (21): 2558.
Khan JS, Rai A, Sundara Rajan R, Jackson TD, Bhatia A. A scoping review of perineural steroids for the treatment of chronic post-herniorrhaphy groin pain. Hernia 2016; 20(3): 367-76.
Khan JS, Margarido C, Devereaux PJ, Clarke H, McLellan A, Choi S. Preoperative celecoxib in noncardiac surgery: A systematic review and meta-analysis of randomized controlled trials. European Journal of Anaesthesia, March 2016; 33(3): 204-214.
Khan JS, Yousef M, Sharma A, Siddiqui N. An estimation for an appropriate end-time for an intraoperative intravenous lidocaine infusion in bowel surgery: A comparative meta-analysis. Journal of Clinical Anesthesia, February 2016; 28: 95-104.
Leslie K, McIlroy D, Kasza J, Forbes A, Kurz A, Khan J, Meyoff C, Allard R, Landoni G, Jara X, Lurati Buse G, Candiotti K, Lee H-S, Gupta R, VanHelder T, Purayil W, De Hert S, Treschan T, Devereaux PJ. Neuraxial block and postoperative epidural analgesia: effects on outcomes in POISE-2 trial. British Journal of Anaesthesia 2016; 116(1): 100-12.
Sharma A, Khan JS, Bainey KR. Preoperative stress tests – Superfluous investigations resulting in excessive treatment delay: A teachable moment. JAMA Internal Medicine 2015; 175(10): 1610-1611.
Bessissow A, Khan J, Devereaux PJ, Alvarez-Garcia J, Alonso-Coello P. Postoperative atrial fibrillation in non-cardiac and cardiac surgery : An overview. Journal of Thrombosis and Haemostasis 2015; 13: S304-S312.
Khan J, Gilbert J, Sharma A, LeManach Y, Yee D. Perspectives of anesthesia residents training in Canada on fellowship training, research, and future practice location. Canadian Journal of Anesthesia 2015; 62(9): 956-63.
Khan J, Katz J, Montbriand J, Ladak S, McCluskey S, Srinivas C, Ko R, Grant D, Bradbury A, LeManach Y, Clarke H. Surgically-placed abdominal wall catheters on postoperative analgesia and outcomes after live liver donation. Liver Transpl., April 2015; 21(4): 478-86.
Karanicolas P, Cleary S, McHardy P, McCluskey S, Sawyer J, Ladak S, Law C, Wei A, Coburn N, Ko R, Katz J, Kiss A, Khan J, Srinivas C, Lam-McCulloch J, Clarke H. Medial Open Transversus Abdominis Plane (Motap) Catheters For Analgesia Following Open Liver Resection: Study Protocol For A Randomized Controlled Trial. Trials 2014; 15: 241 – 247.
Khan J, Mariappan R, Venkatraghavan L. Entropy as an indicator of cerebral perfusion pressure in patients with increased intracranial pressure. Journal of Anaesthesiology and Clinical Pharmacology 2014; 30 (3): 409-411.
Khan J, Alonso-Coello P, Devereaux PJ. Myocardial injury after noncardiac surgery. Current Opinions in Cardiology 2014; 29(4): 307-311.
Devereaux, PJ, Mrkobrada M, Sessler DI, et al. on behalf of the POISE-2 Investigators (Khan J). Aspirin in Patients Undergoing Noncardiac Surgery. New England Journal of Medicine 2014; 370: 1494 – 1503.
Devereaux PJ, Sessler DI, Leslie K, et al. on behalf of the POISE-2 Investigators (Khan J). Clonidine in Patients Undergoing Noncardiac Surgery. New England Journal of Medicine 2014; 370: 1504 – 1513.
Banglawala S, Gill M, Dhillion N, Khan J, Gupta M, Psaltis A, Schlosser R, Sommer D. Nasal Packing After Septoplasty: Cardiopulmonary Impact. JAMA Otolaryngol Head Neck Surg 2014; 140 (3): 253-258.
Alam A, Khan J, Liu J, Klemensberg J, Griesman J, & Bell CM. Characteristics and rates of disciplinary findings amongst anesthesiologists by professional colleges in Canada. Canadian Journal of Anesthesia 2013; 60 (10): 1013-1019.
Khan J, Gill M, Clarke H. The onset of Benign Paroxysmal Positional Vertigo after Total Laparoscopic Hysterectomy in Trendelenburg Position. Journal of Minimally Invasive Gynecology 2012; 19(6): 798-800.
Khan J, Gill M, Seth P, Clarke H. Chronic pain: an overview of its issues. McMaster University Medical Journal. 2012; 9(1): 36-38.