Critical Care Clinical Research Unit - Sunnybrook

Research Unit Description

The research unit is based in the Department of Critical Care Medicine at Sunnybrook Health Sciences Centre. It is composed of a group of like-minded clinician scientists and educators who are interested in further critical care medicine through the development, conduct, completion and implementation of high quality research and education in critical care medicine.

Research Focus

The focus of the group is performing high quality clinical epidemiology in the field of critical care medicine. This includes high quality clinical trials, cohort studies, database studies and meta-analyses in critical care medicine. The group has been very successful in attracting funding and publishing papers in high quality medical journals including 380 peer-reviewed papers in the last 6 years and $30 million of grant income. Their educational aims mirror their research aims to innovate in the delivery and development of medical education for trainees in critical care medicine from all backgrounds.

Selected Publications 

  1. Dev SP, Stefan RA, Saun T, Lee S. Videos in clinical medicine. Insertion of an intraosseous needle in adults. N Engl J Med. 2014 Jun 12;370(24):e35. doi: 10.1056/NEJMvcm1211371. Review. PubMed PMID: 24918394.
  2. Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH; OSCAR Study Group. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med. 2013 Feb 28;368(9):806-13. doi: 10.1056/NEJMoa1215716. Epub 2013 Jan 22. PubMed PMID: 23339638.
  3. Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011 Apr 7;364(14):1293-304. doi: 10.1056/NEJMoa1011802. PubMed PMID: 21470008.
  4. Dev SP, Hillmer MD, Ferri M. Videos in clinical medicine. Arterial puncture  for blood gas analysis. N Engl J Med. 2011 Feb 3;364(5):e7. doi: 10.1056/NEJMvcm0803851. PubMed PMID: 21288091.
  5. Fowler RA, Jouvet P. Paediatric mortality related to H1N1 infection in England. Lancet. 2010 Nov 27;376(9755):1808-10. doi: 10.1016/S0140-6736(10)61385-2. Epub 2010 Oct 26. PubMed PMID: 21030070.
  6. Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD. Critical care and the global burden of critical illness in adults. Lancet. 2010 Oct 16;376(9749):1339-46. doi: 10.1016/S0140-6736(10)60446-1. Epub 2010 Oct 11. Review. PubMed PMID: 20934212.
  7. Jones A, Barrett N, Scales D, Beale R. Ventilatory support versus ECMO for severe adult respiratory failure. Lancet. 2010 Feb 13;375(9714):550-1; author reply 551. doi: 10.1016/S0140-6736(10)60223-1. PubMed PMID: 20159283.
  8. Young D, Harrison DA, Cuthbertson BH, Rowan K; TracMan Collaborators. Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA. 2013 May 22;309(20):2121-9. doi: 10.1001/jama.2013.5154. PubMed PMID: 23695482.
  9. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hébert P, Sabri E, Meade M; SLEAP Investigators; Canadian Critical Care Trials Group. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA. 2012 Nov 21;308(19):1985-92. Erratum in: JAMA. 2013 Jan 16;309(3):237. PubMed PMID: 23180503.
  10. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669. PubMed PMID: 22797452.
  11. Prasad M, Holmboe ES, Lipner RS, Hess BJ, Christie JD, Bellamy SL, Rubenfeld GD, Kahn JM. Clinical protocols and trainee knowledge about mechanical ventilation. JAMA. 2011 Sep 7;306(9):935-41. doi: 10.1001/jama.2011.1226. PubMed PMID: 21900133.
  12. Bell CM, Brener SS, Gunraj N, Huo C, Bierman AS, Scales DC, Bajcar J, Zwarenstein M, Urbach DR. Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases. JAMA. 2011 Aug 24;306(8):840-7. doi: 10.1001/jama.2011.1206. PubMed PMID: 21862745.

Brian Cuthbertson, MD

P: (416) 480-6100 ext 2895
F: (416) 480-4999


Research Unit Members

Dr. Brian Cuthbertson, MD: Prinicpal Investigator
Dr. Andre Amaral, MD: Clinicians Quality Improver
Dr. Neill Adhikari, MD MSc: Clinician Scientist
Dr. Shelly Dev, MD: Clinician Educator
Dr. Shannon Goddard, MD PhD
Dr. Rob Fowler, MD MSc: Clinician Scientist

Dr. Victoria McCredie: MB ChB PhD Candidate
Dr. Dominique Piquette, MD PhD: Clinician Educator
Dr. Louise Rose, PhD: Clinician Scientist
Dr. Gordon Rubenfeld, MD MSc: Clinician Scientist
Dr. Damon Scales, MD PhD: Clinician Scientist
Dr. Taz Sinuff, MD PhD: Clinician Scientist
Dr. Hannah Wunsch, MD MSc: Clinician Scientist
Nicole Marinoff, MSc: Research Coordinator
Ruxandra Pinto, PhD: Statistician